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Visualizzazione post con etichetta epidemiologia. Mostra tutti i post
Visualizzazione post con etichetta epidemiologia. Mostra tutti i post

lunedì 26 marzo 2018

Un indubbio aumento dei tumori al cervello in UK



http://microwavenews.com/news-center/gbms-rising-uk

Da un'elaborazione statistico epidemiologica  dei tumori al cervello dal 1995 al 2016 viene rilevato un leggero incremento dei tumori nel periodo ma, cosa molto più sconcertante, un forte incremento di quelli più invasivi e aggressivi.

E' quanto si legge dalla pubblicazione del lavoro
https://www.hindawi.com/journals/jeph/aip/7910754/
di A. Phillips ed altri.


Il lavoro si raccorda con i recenti articoli di Hardell, che già avevano portato alla richiesta a WHO di rivedere la classificazione della pericolosità delle radiofrequenze.

martedì 9 maggio 2017

Cancerogene: lo dice anche Mr Bradford Hill ...!

Nel 1965 - quindi ben prima dell'avvento dei telefonini ... - Furono individuati dei criteri guida per Valutare i RISULTATI degli studi epidemiologici. Per gran lunga SI che dalla letteratura scientifica si Possa Switch to delle Regole di vita.

I soliti - per fortuna che ci Sono - Hardell e Carlberg Hanno Applicato i criteri guida,  cre Allora e codificati dal ricercatore Bradford Hill, morto nel 1991, Ai Dati epidemiologici DISPONIBILI in letteratura.


Conclusioni: Le radiofrequenze debbono Essere trattate venire Agenti cancerogeni che portano alla Produzione di glioma.



Valutazione del Cellulare e Telefono senza fili Uso e Glioma rischio Utilizzando la Bradford Hill Punti di vista dal 1965, per associazione o Nesso di causalità

Carlberg M, L. Hardell Valutazione della Cellulare e Telefono senza fili Uso e Glioma rischio Utilizzando la Bradford Hill Punti di vista dal 1965, per associazione o Nesso di causalità. Biomed Res Int. 2017; 2017: 9.218.486. doi: 10,1155 / 2017/9218486. Epub 2017 16 marzo.

Astratto

Obbiettivo. punti di vista di Bradford Hill dal 1965 su un'associazione o causalità sono stati utilizzati sul rischio di glioma e l'uso di telefoni cellulari o cordless. Metodi. Tutti e nove i punti di vista sono stati valutati sulla base di studi epidemiologici e di laboratorio. Risultati. Forza: meta-analisi di studi caso-controllo ha dato odds ratio (OR) = 1,90, 95% intervallo di confidenza (CI) = 1,31-2,76 con la massima esposizione cumulativa. Consistenza: il rischio aumenta con la latenza, meta-analisi ha dato nel gruppo di latenza dei 10 anni OR = 1.62, 95% CI = 1,20-2,19. Specificità: aumento del rischio di glioma era nel lobo temporale. Utilizzando casi di meningioma come gruppo di confronto ancora aumentato il rischio. La temporalità: il rischio più alto era in 20+ gruppo di latenza anni, OR = 2.01, 95% CI = 1,41-2,88, per i telefoni senza fili. gradiente biologica: uso cumulativo di telefoni cellulari ha aumentato il rischio. Plausibilità: studi su animali hanno mostrato una maggiore incidenza di glioma e schwannoma maligno nei ratti esposti a radiazioni a radiofrequenza (RF). C'è aumentata produzione di specie reattive dell'ossigeno (ROS) da radiazione RF. Coerenza: c'è un cambiamento nella storia naturale di glioma e crescente incidenza. Esperimento: gli antiossidanti riducono la produzione di ROS da radiazioni RF. Analogia: v'è un rischio maggiore in soggetti esposti a campi elettromagnetici estremamente bassa frequenza. Conclusione. radiazioni RF deve essere considerato come un agente cancerogeno che causa glioma umano.

https://www.ncbi.nlm.nih.gov/p ubmed / 28401165

martedì 28 febbraio 2017

altre due meta-analisi confermano il rischio di tumore

Ci sono state due pubblicazioni recenti su due importanti riviste internazionali International Journal of Occupational Medicine and Environmental Health,  e  Neurological Sciences.
in cui viene evidenziato come la qualità degli studi epidemiologici analizzati, il tipo di finanziamento ricevuto dai ricercatori ... correlano il rischio relativo di tumore al cervello ! 

vedere qui li link alle note di Joel M. Moskowitz  
http://www.saferemr.com/2017/02/long-term-cell-phone-use-increases.html




Come vedete l'odds ratio (il rischio relativo) è proporzionale alla qualità dello studio [secondo dei criteri definiti anni addietro!] e al finanziamento da parte del governo!!!

domenica 27 marzo 2016

Tumore al cervello è il più frequente tra i tumori che colpiscono gli adolescenti

Un corposo studio di indagine statistica nei database della sanità americana, finanziata dalla American Brain Tumor Association arriva alla conclusione che la tipologia di tumore che più comunemente colpisce i giovani dai 15 ai 19 anni  è quello al cervello o al sistema nervoso centrale.  Mentre esso è il terzo più comune nella popolazione 15-39.

Ovviamente non viene preso in esame il tema di quali possano essere le cause più frequenti ... sicuramente perché non sono dati disponibili in questi database, immagino ...

venerdì 1 gennaio 2016

Usare molto il cellulare fa ingrassare !


Apparentemente questo è il risultato di uno studio epidemiologico inglese COSMOS che sta coinvolgendo oltre 100.000 inglesi per correlare il tipo di utilizzo di  telefono cellulare (ma non è richiesto se presenti  in ambienti con wifi) ed una serie di informazioni 'oggettive' ovvero l'effettivo utilizzo dello stesso tramite dati provenienti dai provider telefonici, l'inquinamento ambientale tra cui elettrosmog da TV riferito al singolo partecipante in base alla sua posizione geografica, questionari online, etc.

Quindi, il risultato ottenuto è che esiste una chiara correlazione tra uso del cellulare e obesità.

E poi ?     Speriamo che questo sia l'unico risultato di questo progetto finanziato - ancora una volta, vedi quello di  Interphone - da Governo ed Società Telefoniche inglesi  e tutto finisca lì !


http://ije.oxfordjournals.org/content/early/2015/11/02/ije.dyv203.long#

domenica 9 agosto 2015

Forte incremento delle morti neurologiche ! che non si spiega con l'età

Importante lavoro del Prof. Colin Pritchard  della Bournemouth University (UK) che ha dimostrato che c'è stato un forte incremento di morti legate a malattie neurologiche.

Conclude che è la 'vita moderna' è responsabile di una sorte di epidemia nascosta che porta a malattie del cervello, spesso con conseguente morte.

Il lavoro  riporta molti dati e confronto con molti altri lavori che raffigurano incrementi tremendi per ad es.  75+ americani donne ed uomini.   Ha preso in considerazione 21 nazioni dell'Occidente.

La conclusione è molto logica:  non c'è una spiegazione causa effetto che porti ad un qualche agente  e  che quindi  giustifichi un tale incremento.  
Lui è lucidamente conseguenziale nel ritenere che solo fattori ambientali (spesso interrelati tra di loro) che determinano questo scenario.
Non indica ovviamente gli EMF ... ma ...




Modern living could be responsible for an ‘almost epidemic’ increase in neurological brain disease.
Published in the journal Surgical Neurology International the study compared 21 Western countries between 1989 and 2010 and found that dementias are starting a decade earlier than they used to in adults.
Furthermore deaths caused by neurological disease have risen significantly in adults aged 55-74, and for adults 75+ the rate has virtually doubled in every Western country in just the last 20 years.
In the US, the problem is particularly acute; neurological deaths in male over 75s have nearly trebled and females rose more than five-fold.
For the first time since records began, more elderly US women died of brain disease than cancer.
Professor Colin Pritchard of Bournemouth University led the study said "The rate of increase in such a short time suggests a silent or even a `hidden' epidemic, in which environmental factors must play a major part, not just aging....

venerdì 31 ottobre 2014

Hardell: si arriva ad un maggiore rischio del 300% per uso celllulare e cordless per più di 25 anni

Altro recentissimo lavoro pubblicato dal team del Prof Hardell su uno studio epidemiologico su oltre 5000 persone, di cui 1500 con diagnosticato tumore al cervello.

il rischio di glioma si incrementa  del +30% nel caso  di uso di cellulare e cordless da più di un anno fino a ben il 300% quando l'uso è prolungato per più di 25 anni.

Il rischio raddoppia per un uso cumulativo di 1500 ore ... che vuol dire pari a 30' al giorno per 8 anni ! Notare bene ...  
Ricordo che uno studio sui consumi di (solo) telefono cellulare, americano datato forse 2010 (?) indicava che l'utilizzo medio degli utenti era di mezz'ora al giorno !   E in un periodo antecedente l'esplosione degli smartphone , del 4G, etc.   
Quindi una grande fetta degli utenti è a fortissimo rischio ,e  non solo i grandi utilizzatori come i media ufficiali ci aveva informato dopo il progetto Interphone.
----------------------------------------------------------------------------------------------------------------



Cell and cordless phone risk for glioma - Analysis of pooled case-control studies in Sweden, 1997-2003 and 2007-2009

L. Hardell, M. Carlberg, Cell and cordless phone risk for glioma - Analysis of pooled case-control studies in Sweden, 1997-2003 and 2007-2009, Pathophysiology (2014), Available online 29 October 2014. http://dx.doi.org/10.1016/j.pathophys.2014.10.001

Abstract


We made a pooled analysis of 2 case-control studies on malignant brain tumours with patients diagnosed during 1997-2003 and 2007-2009. They were aged 20-80 years and 18-75 years, respectively, at the time of diagnosis. Only cases with histopathological verification of the tumour were included. Population-based controls, matched on age and gender, were used. Exposures were assessed by questionnaire. The whole reference group was used in the unconditional regression analysis adjusted for gender, age, year of diagnosis and socio-economic index.

In total 1,498 (89%) cases and 3,530 (87%) controls participated. Mobile phone use increased the risk of glioma, OR = 1.3, 95% CI = 1.1-1.6 overall, increasing to OR = 3.0, 95% CI = 1.7-5.2 in the > 25 year latency group. Use of cordless phones increased the risk to OR = 1.4, 95% CI = 1.1-1.7, with highest risk in the >15-20 year latency group yielding OR = 1.7, 95% CI = 1.1-2.5. The OR increased statistically significant both per 100 h of cumulative use, and per year of latency for mobile and cordless phone use. Highest ORs overall were found for ipsilateral mobile or cordless phone use, OR = 1.8, 95% CI = 1.4-2.2 and OR = 1.7, 95% CI = 1.3-2.1, respectively. The highest risk was found for glioma in the temporal lobe. First use of mobile or cordless phone before the age of 20 gave higher OR for glioma than in later age groups.

http://www.journals.elsevier.com/pathophysiology/

Key Findings

The relative risk of glioma for wireless (cell and cordless) phone use increased from 1.3 (95% CI = 1.1-1.6) for more than 1 year of use to 3.0 (95% CI = 1.7-5.2) for more than 25 years of use (Table 2).
The ipsilateral (same side of head where phone was used) relative risk of gloma for cell phone use increased from 1.8 (95% CI = 1.4-2.2) for more than 1 year of use to 4.6 (95% CI = 2.1-10.0) for more than 25 years of use (Table 5).

The contralateral (opposite side of head where phone was used) relative risk of gloma for cell phone use increased from 1.1 (95% CI = 0.8-1.4) for more than 1 year of use to 3.2 (95% CI = 1.2-8.6) for more than 25 years of use (Table 5).
The overall relative risk of glioma for 1-122 hours of wireless phone use was 1.2 (95% CI = 0.9-1.4) whereas the risk for more than 1,486 hours was 2.0 (95% CI = 1.6-2.6) (Table 6).
The ipsilateral relative risk of glioma for people who first used mobile phones  at less than 20 years of age was 2.3 (95% CI =1.3-4.2) whereas the risk for those who first used mobile phones at 50 years of age or older was 1.7 (95% CI =1.3-2.2) (Table 8).


Excerpts

Detailed information on materials and methods has been given previously ...For 1997-2003, cases and controls covered central Sweden [13], whereas the 2007-2009 study included the whole country [24] ...

Controls were ascertained from the Swedish Population Registry, covering the whole country and being continuously updated, such that each person was traced by a unique ID number. The registry also records the address to each person. For each case, one control subject of the same gender in the same 5-year group was drawn at random from this registry. They were assigned the same year for cut-off of all exposure as the diagnosis of the each case ...

Exposure was assessed using a mailed questionnaire sent to each person. Regarding use of a mobile phone, the time of average use (min per day) was estimated. The technology has changed since the first introduction of mobile phones. The first generation was analogue phones with an output power of 1 W at about 900 MHz followed by the 2nd generation GSM phones (2G) with either 900 or 1800 MHz frequency and with a pulsed output power. The mean output power was of the order of tens of mW. In the 3rd generation phones (3G) the output is more to be characterized as amplitude modulated than pulsed and the output power is of the order of tens of μW ...

Some special questions covered the extent of use in a car with an external antenna, and use of a hands-free device, both regarded as non- exposure to RF-EMF. The ear mostly used during phone calls, or equally both ears, was also noted.

Use of cordless desktop phones was covered by similar questions; years, average daily use, use of a hands-free device, and preferred ear. The procedure was conducted without knowledge of case/control status. Use of the wireless phone was referred to as ipsilateral (>50% of the time) or contralateral (<50% of the time) in relation to tumour side....

The questionnaire also contained a number of questions relating to the overall working history, exposure to different chemicals and other agents, smoking habits, X-ray investigations of the head and neck, and heredity traits for cancer ...

Adjustment was made for the matching variables gender, age (as a continuous variable) and year of diagnosis. It was also made for socio-economic index (SEI) divided into 4 categories ...

In total, 1,691 cases fulfilling the inclusion criteria were enrolled. Of these cases, 1,498 (89%) answered the questionnaire, of whom 879 were men and 619 women. The mean age was 52 (median 54, range 18-80) ...

Of the 4,038 controls, 3,530 (87%) participated, 1,492 men and 2,038 women. The mean age was 54 (median 55, range 19-80) ...

The median latency time for use of mobile phones in glioma cases was 9.0 years (mean 10.1, range 2-28). The corresponding results for cordless phones were median 7.0 years (mean 8.0, range 2-21) ... Analogue phones gave OR = 1.6, 95% CI = 1.2-2.0, increasing to OR = 4.8, 95% CI = 2.5-9.1 in the latency group of
>25 years. Note that the latency time was counted from the first use of the specific telephone type; for instance, a 2G digital phone user may have previously used an analogue phone.

Use of digital 2G phones gave overall OR = 1.3, 95% CI = 1.1-1.6 increasing to OR = 2.1, 95% CI = 1.5-3.0 with a latency >15-20 years, the longest latency interval. The results for digital 3G phones showed highest risk in the >5-10 years latency group, OR = 4.1, 95% CI = 1.3-12 ...

Digital type of mobile phones (2G, 3G) gave in total OR = 1.3, 95% CI = 1.1-1.6, increasing to OR = 2.1, 95% CI =1.5-3.0 in the longest latency group (>15-20 years).

Use of cordless phones gave OR = 1.4, 95% CI = 1.1-1.7, with highest risk in the latency group >15-20 years, OR = 1.7, 95% CI = 1.1-2.5 ...
The digital type of wireless phones (2G, 3G and/or cordless phone) gave OR = 1.3, 95% CI = 1.1-1.6, increasing to OR = 1.6, 95% CI = 1.3-2.0 in the latency group >5-10 years, then tending to drop, and again increasing to OR = 2.0, 95% CI = 1.5-2.8 risk in the latency group >15-20 years.

The group of total wireless phone use (mobile phone and/or cordless phone) gave similar results to mobile phone use, with increasing risk with latency yielding highest risk in the longest latency group >25 years; OR = 3.0, 95% CI =1.7-5.2.

The risk increased per additional year of latency given for wireless phones; OR = 1.032, 95% CI = 1.019-1.046 ...

Wireless phone total use (>1,486 h) gave OR = 2.0, 95% CI = 1.6-2.6 in the 4th quartile, with similar results for total mobile and cordless phone use.

ORs increased statistically significant per 100 h of cumulative use for all types of phones (Table 3). Wireless phone increased the risk OR = 1.011, 95% CI = 1.008-1.014 per 100 h of cumulative use ...

The risks of glioma, based on different age groups for first use of wireless phones, are given in Table 8. Regarding mobile phone use, the highest OR was obtained for first use before the age of 20 years, OR = 1.8, 95% CI = 1.2-2.8. The risk increased for ipsilateral use to OR = 2.3, 95% CI = 1.3-4.2. Cordless phone gave OR = 2.3, 95% CI = 1.4-3.9 in total for the age group < 20 years, increasing to OR = 3.1, 95% CI = 1.6-6.3 for ipsilateral use.

Most of the types of malignant brain tumours were glioma (n = 1,380, 92.1%). The most malignant variety, astrocytoma grade IV (glioblastoma multiforme)
constituted 50.3% of the gliomas ... This study clearly shows an increased risk for glioma associated with use of both mobile and cordless phones, a risk that increased significantly with latency and cumulative use. The highest risk was in the longest latency group (> 25 years), giving a statistically significant 3-fold increased risk. Overall a high risk was found for use of the third generation (3G) mobile phones, with OR=4.1, 95% CI = 1.3-12 in the latency group >5-10 years. The risk increased with 4.7% per 100 h cumulative use and with 15.7% per year of latency.

Children and adolescents are more exposed to RF-EMF than adults due to thinner skull bone, higher conductivity in the brain tissue, and a smaller head. Also the developing brain is more vulnerable than in adults and it is still developing until about 20 years of age [31]. We analysed glioma risk in different age groups for first use of a wireless phone. Regarding both mobile and cordless phones OR was highest among subjects with first use before 20 years of age. The risk increased further for ipsilateral use to OR = 2.3, 95% CI = 1.3-4.2 for mobile phone use and to OR = 3.1, 95% CI = 1.6-6.3 for cordless phone use. These results are
consistent with our previous findings [8,15,29,30].

One strength of our study was the high percentage of participating cases and controls, 86% and 87%, respectively, making it unlikely that selection bias influenced the results ...

Recall bias might have been an issue, such that cases would have overestimated their use of  wireless phones. To address this point, we used meningioma cases from the same study as the reference entity in one analysis, which showed an increased risk of glioma with wireless phone use. Thus it is unlikely that our present results using population-based controls are explained by recall bias.
Of certain interest is the higher risk we observed for 3G mobile phone use compared with other types. However, this observation was based on short latency and rather low numbers of exposed subjects. Contrary to 2G GSM, 3G universal global telecommunications system (UMTS) mobile phones emit wide-band microwave (MW) signals. Hypothetically, UMTS MWs may result in higher biological effects compared to GSM signal because of eventual "effective" frequencies within the wideband [32,33]. To our knowledge, there are only two mechanistic studies, which compare effects of 2G and 3G signals using the same experimental approach under well-defined conditions of exposure [32,34] ...

In analysis of survival of glioma cases in our previous studies [13,15,25], we found generally a decreased survival of glioma cases with long-term and high cumulative use of wireless phones [36]; this indicates a complex biological effect from RF-EMF exposure and strengthens a causal association between glioma and the use of wireless phones.

Conclusion. We previously analysed the evidence on glioma associated with the use of  wireless phones using the Hill criteria [20]. We concluded that glioma and also acoustic neuroma are caused by RF-EMF emissions from wireless phones, and thus regarded as carcinogenic, under Group 1 according to the IARC classification, indicating that current guidelines for exposure should be urgently revised. This pooled analysis gives further support to that conclusion regarding glioma.



 

lunedì 9 giugno 2014

Studio epidemiologico francese: 15 ore/mese = 200-300% di maggiore probabilità di tumore !

E' stato pubblicato un importante studio epidemiologico Francese secondo il quale un uso del telefono cellulare con una media negli ultimi 5 anni di 15 ore/mese (che sono poi, in media, 30 minuti al giorno ... [Nota bene, non tanti: quanti di noi lo usano tanto ?!] ) aumenta di due - tre volte la probabilità di glioma e meningioma al cervello.

Questo studiio segue gli ulteriori sviluppi   dello svedese Hardell che vanno verso una sempre più chiara conferma della necessità di revisione della classificazione delle EMF da 'possibile' a 'probabile' cancerogeni.


sabato 3 maggio 2014

Allarme da Bioinitiative Group: le evidenze scientifiche su danni tumorali aumentano sempre più

Dalla lettura degli studi pubblicati dal 2012 al 2014 si ha un'evidenza sempre maggiore del rischio di tumori (glioma) e neuroma con l'uso di telefoni cellulari e cordless. E' quanto sottonea Prof. Lennart Hardell . I livelli di esposizione limite proposti tanti anni fa da ICNIRP sono inadeguati.

Qui c'è una intervista a Olle Johansson, con sottotitoli in inglese e spagnolo.



The BioInitiative Working Group says evidence for health risk from wireless
tech is growing stronger and warrants immediate action. The Group released
a mid-year update covering new science studies from 2012 to 2014.

New studies intensify medical concerns about malignant brain tumors from
cell phone use. “There is a consistent pattern of increased risk for glioma
(a malignant brain tumor) and acoustic neuroma with use of mobile and
cordless phones” says Lennart Hardell, MD, PhD at Orebro University,
Sweden, according to studies released in 2012 and 2013. “Epidemiological
evidence shows that radiofrequency should be classified as a known human
carcinogen. The existing FCC/IEEE and ICNIRP public safety limits are not
adequate to protect public health.”

http://www.youtube.com/watch?v=LsQ2I41Wp70

The BioInitiative reports nervous system effects in 68% of studies on
radiofrequency radiation (144 of 211 studies) in 2014. This has increased
from 63% in 2012 (93 of 150 studies) in 2012. Studies of extremely-low
frequency radiation are reported to cause nervous system effects in 90% of
the 105 studies available in 2014. Genetic effects (damage to DNA) from
radiofrequency radiation is reported in 65% (74 of 114 studies); and 83%
(49 of 59 studies) of extremely-low frequency studies.


Mobile wireless devices like phones and tablets are big sources of
unnecessary biological stress to the mind and body that can chip away at
resilience over time. The Report warns against wireless in schools. Schools
should provide internet access without Wi-Fi.

"It is essentially an unregulated experiment on children's health and
learning. Microwave from wireless tech disrupts thinking – what could be
worse for learning? Technology can be used more safely with wired devices
that do not produce these biologically-disruptive levels of microwave
radiation" said Cindy Sage, Co-Editor of the BioInitiative Report.

Federal programs like
ConnectED
<http://www.whitehouse.gov/blog/2013/06/06/what-connected>
and
E-Rate are calling for wireless classrooms while ignoring the health
evidence. Hyperactivity, concentration problems, anxiety, irritability,
disorientation, distracted behavior, sleep disorders, and headaches are
reported in clinical studies.

Government reviews on health impacts of wireless radiofrequency radiation
from the European Union and Australia continue to be inconclusive largely
because they require certainty before issuing warnings. The FCC review of
health impacts from wireless technologies is still underway, but has not
affected the federal push for wireless classrooms.

See: www.bioinitiative.org
Contact: info@bioinitiative.org
David O. Carpenter, MD dcarpenter@albany.edu

sabato 30 novembre 2013

Studio epidemiologico inglese riporta forte relazione tra cellulare e neurinomi


In questo studio condotto dai soliti negazionisti , omettono come sempre le evidenze e smentiscono se stessi. Quasi triplicano i neurinomi  con la significatività statistica  e neanche viene riportato nelle conclusioni , anzi, capovolto!.
 



Mobile phone use and risk of brain neoplasms and other cancers: prospective study
2.   Kirstin Pirie1,
3.   Joachim Schüz2,
5.   Valerie Beral1,
6.   Jane Green1,
7.   for the Million Women Study Collaborators
+ Author Affiliations
1.    1Cancer Epidemiology Unit, University of Oxford, UK, 2International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France
1.    *Corresponding author. Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, UK. E-mail: vicky.benson@ceu.ox.ac.uk
2.    The members of Million Women Study Collaborators are listed in the Supplementary Appendix at IJE online
·         Accepted March 28, 2013.
Abstract
Background Results from some retrospective studies suggest a possible increased risk of glioma and acoustic neuroma in users of mobile phones.
Methods The relation between mobile phone use and incidence of intracranial central nervous system (CNS) tumours and other cancers was examined in 791 710 middle-aged women in a UK prospective cohort, the Million Women Study. Cox regression models were used to estimate adjusted relative risks (RRs) and 95% confidence intervals (CIs). Women reported mobile phone use in 1999 to 2005 and again in 2009.
Results During 7 years’ follow-up, 51 680 incident invasive cancers and 1 261 incident intracranial CNS tumours occurred. Risk among ever vs never users of mobile phones was not increased for all intracranial CNS tumours (RR = 1.01, 95% CI = 0.90–1.14, P = 0.82), for specified CNS tumour types nor for cancer at 18 other specified sites. For long-term users compared with never users, there was no appreciable association for glioma (10+ years: RR = 0.78, 95% CI = 0.55–1.10, P = 0.16) or meningioma (10+ years: RR = 1.10, 95% CI = 0.66–1.84, P = 0.71). For acoustic neuroma, there was an increase in risk with long term use vs never use (10+ years: RR = 2.46, 95% CI = 1.07–5.64, P = 0.03), the risk increasing with duration of use (trend among users, P = 0.03).
Conclusions In this large prospective study, mobile phone use was not associated with increased incidence of glioma, meningioma or non-CNS cancers ?
 

martedì 23 luglio 2013

Altro studio di Hardell su relazione tumore al cervello e uso del cellulare

Recentissimo articolo pubblicato dal Prof Hardell e coll. in cui si confermano i suoi studi che sono una base importante per la decisione dello IARC di classificare le radiofrequenze come probabili concerogeni.

Qui il ricercatore indica anche un numero inquietante :  100 ore. ovvero correla un uso cumulativo di telefono per 100 ore / annue come statisticamente significativo ai fini della correlazione della incidenza di tumore al cervello.   Vedere l'articolo.

mercoledì 26 giugno 2013

Disinformazione vestita da ricerca scientifica: Danimarca

E' stato riportato uno studio epidemiologico su tumori & uso del telefono cellulare in Danimarca.
Il risultato è  stato che non c'è rilevanza statistica.

Questa conclusione è quella che è stata diffusa dai media, in antagonismo delle conclusioni dello IARC che la classificato le radiofrequenze come possibili concerogeni.

Infatti colpisce come:

- per qualche strano motivo, i GRANDI utilizzatori del cellulare =  chi lo usa per business (o, detto il altro modo, chi non paga la bolletta o la ricarica !!!)  non è stato preso in considerazione !
- nonostante ciò sono stati rilevati degli incrementi , contenuti, ma che non sono stati riportati nelle conclusioni (solo queste vengono lette dai non esperti, guarda caso ...)
- lo studio è stato finanziato al 100% dalla industria (ma no !  strano ....!).

Qui c'è un'analisi critica.

giovedì 28 febbraio 2013

Nuovo studio su Melanoma e possibili cause

Nuovo importante,  molto ben documentato e dettagliato studio di Olle Johansson  di tipo epidemiologico  in cui si affronta la relazione esistente tra un aumento di melanoma riscontrato nei paesi scandivani (ma anche in USA ed altri paesi)  e i danni subiti dal sistema immunitario che perde la sua efficienza nel suo lavoro continuativo di riparazione del DNA danneggiato nelle singole cellule.
Dopo aver confrontato con  dati statistici ed epidemiologici  altri possibili cofattori conclude come questi danni siano legati ad 'abitudini' stabilite dalla vita moderna che porta a comprare letti a rete, cellulari, TV, creme solari abbrozzanti, etc etc    

Dalle tante tabelle statistiche si evidenzia come l'incremento del melanoma è iniziato negli anni 50 e trova una grande correlazione con la introduzione della televisione.

Inoltre  sottolinea che un importante fattore sia  la risonanza del corpo che di fatto è immerso in un ambiente di frequenze 'sensibili'.  Ad es. la frequenza di  87 MHz corrisponde ad una lunghezza d'onda di 1,74 m ovvero la lunghezza del corpo umano medio . Nel caso di riposo su un letto con rete metallica, questa agisce da antenna ed il corpo dorme su una corrente continua ed il corpo  riflette le frequenze, tutt a la notte, notte dopo notte.

If, instead, the most critical factor is body resonance, then the probability of sleeping in a resonant direction would very much depend on the number of surrounding transmitters. The half-wave length at the frequency 87 MHz is e.g., 1.74 m, which matches the human body length quite well. In case you are sleeping on a metal spring mattress which acts as a radio antenna, there is a risk that your body will constantly carry currents caused by reflected and standing waves during the whole night, year after year.

sabato 29 settembre 2012

Nuovo studio Finlandese sull'uso del telefono cellulare


Qui il documento prodotto, in inglese


E' un'indagine epidemiologica svolta dall'Istituto Finlandese sulla Salute  Occupazionale.in parte coordinato con il Progetto Internazionale COSMOS.
Il progetto è stato denominato WIRECOM = Wireless Communication Devices and Human Health.

 Risultati:

- Mal di testa ha almeno qualche volta limitato le usuali attività quotidiane per il 12% dei partecipanti allo studio e circa il 24% era stato disturbato dalla luce quando si ha un mal di testa.
In media il 15% ritiene la propria salute sia equo o compromessa.
Inoltre, i partecipanti hanno riferito i sintomi che si verificano in relazione l'uso del telefono cellulare. Quasi il 10% degli intervistati ha riferito mal di testa, tinnito 15% e il 10% la perdita di udito parziale, in combinato disposto con l'uso del telefono cellulare (sempre, spesso o qualche volta contro mai). Nausea è la sensazione minimo comune (3%) e bruciore nell'orecchio è stato il sintomo più comune (49%).
 
 - due studi sono stati condotti con il PET , con la conclusione che il metabolismo del glucosio nel cervello è sensibilmente ridotto nelle parti del cervello compatibili con l'uso del telefono
- Nel gruppo adulto, il valore SAR di 4 W / kg è stato utilizzato negli esperimenti. È superiore al valore massimo consentito normale GSM SAR di 2 W / kg, ma chiaramente inferiori ai limiti di sicurezza per esposizione a RF. Durante il tempo di esposizione di 20 minuti, una leggera diminuzione degli indicatori di flusso sanguigno della zona frontale è stato trovato. Questo risultato è in accordo con i risultati del Centro di Turku University s per lo studio Neuroscienze Cognitive PET.
La temperatura del canale uditivo aumentata di circa 0,5 ° C durante il tempo di esposizione 20 min. I campioni di sangue sono stati prelevati solo nel gruppo degli adulti, prima e dopo la seduta. La proteina S100 B è prodotto principalmente nel cervello dagli astrociti. ed è stato suggerito per servire come strumento di screening di lesioni CNS. Durante l'esposizione, la concentrazione S100B è diminuito significativamente
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EXECUTIVE SUMMARY
The rapid spread of mobile phones and other wireless communication devices has in-creased the population’s exposure to electromagnetic fields at radio frequencies (RF).Even though the electromagnetic fields emitted by mobile phones and base stations areweak compared to safety limits, public discussion and some research findings have raisedconcern about possible health effects.During the years 1994 – 2007, four national research programmes were carried out inFinnish universities and research institutes, funded mainly by TEKES. The programmesattempted to respond to citizens’ concerns about the possible adverse health effects of mobile phones, and they were part of international cooperation to evaluate the healthrisks of electromagnetic fields at radio frequencies. Although these Finnish and foreignstudies generated a lot of information, there remain still some open questions. Therefore,in January 2009, a new national research project into the health effects of mobile phones’ RF fields was started. The objective was to enable large-scale and reliable research inindependent research institute, hence ensuring public benefit from the findings.The joint project WIRECOM (Wireless Communication Devices and Human Health), wasmade up of four different projects, containing a large-scale international cooperation thatincludes epidemiological monitoring research as well as provocative projects focussing onpossible effects on the head area. The projects dealt with the research questions thatwere the highest priority for the World Health Organisation (WHO), thus supporting theWHO’s planned evaluation of the health risks of RF fields.

The focus of the Finnish Institute of Occupational Health’s (FIOH) sub-project was to clar-ify whether the exposure of trial subjects to the RF fields from GSM phones produces lev-els of temperature change in the tissues of the head area which could be detrimental tothe health of the phone user.

The results of the volunteer tests by preadolescent boys and young adults indicated no significant increase in local ear canal temperatures or superficialcerebral blood flow. Alterations in peripheral thermoregulatory or circulatory autonomicreflexes typically related to the increase in the temperature of brain thermostat were nei-ther found. With the preadolescents boys the used phone transmitting power was themaximum allowed for the general public ( 2 W/kg).In the adult group, the SAR value of 4 W/kg was used in the experiments. It is higherthan the normal allowed maximum GSM SAR value of 2 W/kg, but clearly below thesafety limits for RF exposures. During the exposure time of 20 min, a slight decrease inthe blood flow indicators of the frontal area was found. This finding is in accordance withresults of Turku University’s Centre for Cognitive Neurosciences PET study. The ear canaltemperature increased about 0.5 °C during the 20 min exposure time. The blood sampleswere taken only in the adult group before and after the session. The protein S100 B ismainly produced in the brain by astrocytes. and it has been suggested to serve as ascreening tool of CNS injury. During the exposure the S100B concentration decreasedsignificantly (p<0,01). The levels, however, were within biological normal range both before and after the exposure. Any other significant changes were not found in other bio-chemical markers.The primary interests of the Centre for Cognitive Neuroscience of University of Turku(UTU) were in the possible link between RF exposure and metabolic changes in brain tis-sue, as well as in the link between functional changes in neurobiological mechanisms andcognitive functions. The research was carried out in cooperation with the national PETCentre. Two positron emission tomography (PET) studies were conducted to investigatethe effects of mobile phone radiation on brain glucose metabolism and cerebral blood flow(CBF) using fluorodeoxyglucose ([18F]FDG) and radioactive water ([15O]H2O), respec-tively. The main finding of the FDG-PET study was that the brain glucose metabolism wassignificantly reduced in the temporoparietal junction and anterior temporal lobe of theexposed (right) hemisphere. The SAR value during the exposure was 0.25 W/kg.The Radiation and Nuclear Safety Authority (STUK) was responsible for the construction of the exposure device for the subjects and for measuring exposure (dosimetry) in the othersub-projects. The quality of the numerical source model used was found adequate bycomparing the measured and simulated SAR values in a homogeneous liquid phantom.Also the simulated return loss and center frequencies agreed well with the measured val-ues. The high quality dosimetric assessment of the exposure systems is essential re-quirement for reliable human exposure studies.The fourth sub-project was also carried out by STUK, consisting of monitoring researchinto mobile phone users as part of a large-scale European project. The Finnish COSMOSstudy is a part of international collaborative COSMOS study with a common study proto-col. Besides Finland, national COSMOS study components have been launched in Sweden,Denmark, and the UK (30,000-66,000 participants in each country), and are being pre-pared in the Netherlands and France. International collaboration increases the statisticalpower of the study considerably, which is essential particularly for rare diseases such asbrain tumours (glioma, meningioma) and Parkinson and Alzheimer disease.People who use mobile phones at different levels were invited to take part in the researchand were contacted through their service providers. In the monitoring phase, data aboutthe participants’ incidence rate of illness were collected, and the question as to whetherthere is a link between use of mobile phones and the risk of illness was evaluated. A totalof 15,800 persons have agreed to participate in the study (9.6% of those invited) andabout 13,000 have also filled in the study questionnaire (8.0% of those invited). In thestudy questionnaire participants reported most often having started their use of mobileuse in the mid-1990s. Study participants usually reported having called their mobilephone 1-3 hours per week (38 %); 6 % belonged to the highest category of call time (> 6h per week) and < 1 % belonged to the lowest category (<5 min per week). About 60 %had used one mobile phone and some 5 % had used at least mobile phones during thepreceding three months. Headache had at least sometimes limited usual daily activities for12 % of the study participants and about 24 % had been bothered by light when having aheadache. On average 15 % considered their health being fair or poor. In addition, par-ticipants reported any symptoms occurring in relation to mobile phone use. Almost 10%of the respondent reported headache, 15% tinnitus and 10% partial hearing loss in con- junction with mobile phone use (always, often or sometimes vs. never). Nausea was the least common (3%) and burning sensation in the ear was the most common symptom(49%).All three major Finnish operators (DNA, Elisa and TeliaSonera) agreed to deliver operatordata for the participants upon researchers’ request. Operator data have been receivedfrom all the operators at least for a three month period each year. Study participants arebeing kept up to date about the progress of the study through a newsletter (sent byemail) and through the study web page (www.cosmostutkimus.fi).After the recruitmentperiod, the Finnish COSMOS is now entering the follow-up phase. We aim to send the firstfollow-up questionnaires in 2013 to those recruited in 2009. The study is expected tocontinue until at least 2020 or beyond.

 

OPEN QUESTIONS AND RECOMMENDATIONS

 

Research findings of both FIOH and UTU indicated that the RF exposure from the mobilephone can affect the brain metabolism and cerebral blood flow. However, conflicting re-ports have been published from other research groups on the brain glucose metabolismafter the RF exposure. There is a need for replication of the present results and to deter-mine possible dose-response relations using different RF exposure intensities. It is oneimportant way to evaluate the causality of the events. As the changes in the brain arevery difficult to measure, the research should be designed to use independent methodolo-gies (e.g. PET and NIRS) on the same physiological function. Similar results by independ-ent methods would give more credibility to the results.The effect of local SAR on brain glucose metabolism could be studied in the future with asetup delivering smaller and better defined and targeted exposed volume. With a dipole orplanar antenna the exposure could be targeted to a certain brain lobe. Higher SAR valuescould be used to study the dose-dependence of the changes in metabolism.A major threat for the future of the Finnish research programme is the lack of continuedfunding.

FUNDING
The main funder of the WIRECOM - programme was Tekes – the Finnish Funding Agencyfor Technology and Innovation. The programme received funding also from Nokia, Teli-aSonera and Elisa as well as from the participating research institutes. The Finnish Insti-tute of Occupational Health was the coordinator of the project.


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New mobile phone research results from Finland

Main findings:

- Headache had at least sometimes limited usual daily activities for 12 % of the study participants and about 24 % had been bothered by light when having a headache. On average 15 % considered their health being fair or poor. In addition, participants reported any symptoms occurring in relation to mobile phone use. Almost 10% of the respondent reported headache, 15% tinnitus and 10% partial hearing loss in conjunction with mobile phone use (always, often or sometimes vs. never). Nausea was the least common (3%) and burning sensation in the ear was the most common symptom (49%).

- Two positron emission tomography (PET) studies were conducted to investigate the effects of mobile phone radiation on brain glucose metabolism and cerebral blood flow (CBF) using fluorodeoxyglucose ([18F]FDG) and radioactive water ([15O]H2O), respectively. The main finding of the FDG-PET study was that the brain glucose metabolism was significantly reduced in the temporoparietal junction and anterior temporal lobe of the exposed (right) hemisphere. The SAR value during the exposure was 0.25 W/kg.

- In the adult group, the SAR value of 4 W/kg was used in the experiments. It is higher than the normal allowed maximum GSM SAR value of 2 W/kg, but clearly below the safety limits for RF exposures. During the exposure time of 20 min, a slight decrease in the blood flow indicators of the frontal area was found. This finding is in accordance with results of Turku University s Centre for Cognitive Neurosciences PET study. The ear canal temperature increased about 0.5 °C during the 20 min exposure time. The blood samples were taken only in the adult group before and after the session. The protein S100 B is mainly produced in the brain by astrocytes. and it has been suggested to serve as a screening tool of CNS injury. During the exposure the S100B concentration decreased significantly.

http://www.ttl.fi/en/publications/Electronic_publications/Documents/WIRECOM.pdf

giovedì 8 dicembre 2011

Recentissimo studio accerta incremento del cancro in giovani

In un lavoro scientifico in via di pubblicazione nella importante rivista Bull Cancer, si riferisce delle conclusioni di studi epidemiologici e statistici su ammalati di tumori in Francia.

Mentre c'è una generale diminuzione negli ultimi 25 anni della mortalità per cancro (grazie alla prevenzione, indagini strumentali, etc.) , dal 1998 al 2005 si è misurato un unico sensibile incremento che è quello dei tumori al cervello dei giovani !!!! Pazzesco





Bull Cancer. 2011 Dec 5. [Epub ahead of print]
Cancer before age 40 in France.
Fayard F, Guérin S, Hill C.
Source

Institut Gustave-Roussy, service de biostatistique et d'épidémiologie, 39 bis, rue Camille-Desmoulins, 94800 Villejuif, France.
Abstract

Cancer is a rare pathology before the age of 40: a total of 14,000 new cases have been diagnosed in patients under age 40 in 2005, 1,700 under age 15 and 12,500 in the age-group of 15 to 39, this represents 4% of the cancers diagnosed in 2005. The number of deaths is small: in 2008, 2,235 patients died before age 40 in France, 246 under age 15 and 1,989 between age 15 and 39; this corresponds to 1% of the cancer deaths in 2008. The incidence increased between 1980 and 2005, both in the population aged 0 to 14 and in the population aged 15 to 39. Overall, cancer mortality has been decreasing for more than 25 years. The only increase in mortality is observed for brain tumours in children. The overall incidence increase is mostly due to the extension of screening coverage and to improvements in diagnostic procedures. The decrease observed for cervix cancer and lung cancer in men demonstrates the efficacy of screening and of tobacco smoking prevention. The mortality decrease is explained both by improved treatments and by the decreased incidence of some types of cancer. The increasing brain tumours mortality in children is worrying.