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Visualizzazione post con etichetta effetti genotossici. Mostra tutti i post
Visualizzazione post con etichetta effetti genotossici. Mostra tutti i post

mercoledì 20 settembre 2017

Presentati i risultati della ricerca del National Toxicology Program (USA): si evidenziano modifiche al DNA

... 'seconde' anticipazioni dei risultati del più grande e costoso progetto di ricerca finanziato sulla evidenzi azione degli effetti delle RF sulla salute, sono stati presentati giorni fa ad un congresso scientifico.

La sperimentazione è stata eseguita su topi e ratti ed, in sintesi, sono stati accertati dei danni cromosomici e danni al DNA ... e essi concludono che:  " la esposizione a RF ha il potenziale per indurre danni misurabili del DNA sotto certe condizioni di esposizione ..." 

I lavori saranno pubblicati completamente ad inizi 2018. Il progetto era stato richiesto e finanziato da FDA (Ministero per Alimentazione e Medicina americano) nel 1999.

Si va verso una sempre maggiore chiarezza !
Ora WHO cambierà la propria impostazione ?  oppure ICNIRP (che continua a spergiurare che gli effetti sono solo quelli termici) riuscirà a tenere bloccato il WHO ?!




Updated Sep 20, 2017


Scientists from the National Toxicology Program presented their data on the genotoxicity of cell phone radiation in rats and mice at the annual meeting of the Environmental Mutagenesis and Genomics Society held in Raleigh, North Carolina from September 9-13, 2017.

Male and female rats and mice were exposed to 2G cell phone radiation, either CDMA or GSM, for 18 hours per day in 10 minute intervals. The rats were exposed to cell phone radiation at 1.5, 3, or 6 W/kg specific absorption rate (SAR) for 19 weeks from gestation day 5. The mice were exposed to radiation at 2.5, 5, or 10 W/kg SAR for 13 weeks from postnatal day 5.

DNA damage was assessed in three brain regions, in liver cells and in blood leukocytes using the comet assay. Chromosomal damage was assessed in peripheral blood erythrocytes using the micronucleus assay. 

DNA damage was significantly increased:

  • in the frontal cortex of male mice from either CDMA or GSM cell phone radiation exposure, 
  • in peripheral leukocytes of female mice from CDMA exposure, and
  • in the hippocampus of male rats from CDMA exposure.
There were no significant increases in micronucleated red blood cells in rats or mice. 

The authors concluded that, "exposure to RFR [radio frequency radiation] has the potential to induce measurable DNA damage under certain exposure conditions."

The NTP is scheduled to publish a complete report about its cell phone radiation studies in early 2018. The FDA called for this research in 1999.

Here is the abstract for this presentation.


Paper presented at annual meeting of Environmental Mutagenesis and Genomics Society,
Raleigh, North Carolina, September 9-13, 2017.

domenica 28 agosto 2016

Nuovo Report della University di Vienna e Fondo di sicurezza sociale austriaco


E' stato appena ufficializzato il secondo report, per ora in tedesco, la versione in inglese arriverà a breve.

Il focus è sugli effetti non termici delle radiofrequenze .
Qui sotto c'è una sintesi non ufficiale prodotta da Katharina Gustavs.

Research Report ATHEM-2
Investigation of Nonthermal Effects of Electromagnetic Fields in the Cell Phone Frequency Range
A Joint Project of the Austrian Workers' Compensation Board (AUVA – Allgemeine Unfallversicherungsanstalt) and the Medical University of Vienna (MUW – Medizinische Universität Wien)
2016 – AUVA Report No. 70

Abstract translated by Katharina Gustavs (25 August 2016)
The ATHEM-2 Project on the Investigation of Nonthermal Effects of Electromagnetic Fields in the Cell Phone Frequency Range is a follow-up study of the ATHEM-1 Project (2002-2008). 
Cell phones transmit and receive radio-frequency electromagnetic fields (RF EMF). Anybody who uses cell phones is exposed to these fields. The ATHEM-2 Project studied not only cognitive effects, but also if and how RF EMF exposures change cells of the human body. One main area of the study focused on laboratory tests of cellular mechanisms of possible genotoxic effects. To ensure quality assurance, the planned tests were reviewed by external experts prior to the start of the project. All tests were carried out as “double blind” experiments. During exposure and during the processing of test samples, neither the volunteer subjects nor the scientists carrying out the experiments knew the actual exposure conditions.
During the human experiments, the buccal mucosa of the volunteer subjects was exposed for two-hour periods on five consecutive days. The nonexposed opposite buccal mucosa served as a control. During the exposure, effects on cognitive performance were examined. The exposure shortened the reaction time, while the error rate increased. For more complex processes such as memory tests, both reaction time and error rate increased during exposure. Two and three weeks, respectively, after the HF EMF exposure, buccal mucosa cells were sampled and analyzed. Minor genotoxic and cytotoxic effects were found, pointing to an accumulation of exposure effects.
The in vitro laboratory tests regarding genotoxicity confirmed that there are cells that are more sensitive to RF electromagnetic fields and others that are less sensitive. The existence of a latency period (time from the start of exposure until the onset of effects) was also confirmed. As a cellular mechanism, it was observed that RF EMF exposure oxidizes the DNA and thus can make DNA more fragile. In cells exposed to additional stress, the RF EMF exposure increased the DNA breakage rate. We observed cells that activate specific cellular repair mechanisms during RF EMF exposure. This finding on the one hand confirms that DNA damage has occurred and on the other hand supports the assumption that the damage can be repaired. DNA changes that were triggered in this manner disappear after ca. two hours. 
None of the effects that were observed allow any conclusions to be made about direct harmful health effects. However, they constitute a potential risk for exposed persons. Simple precautionary measures taken by the user can reduce the exposure and can therefore minimize this risk. Specific precautionary measures include, among other things, not carrying a cell phone on the body but in a purse or handbag and—during a call—using the speakerphone or a headset.



diagnose:funk summaries of the ATHEM project (in German):
https://www.diagnose-funk.org/publikationen/artikel/detail?newsid=1115

mercoledì 15 luglio 2015

Un importante articolo correla al 93% EMF e effetti ossidativi nelle cellule


Riporto il link ad un articolo recentissimo su
Electromagn Biol Med  

di un gruppo di ricercatori di diverse nazioni, che è stato salutato come di notevole valore.

Si fa un'analisi  di un notevole numero di articoli pubblicati su riviste peer reviewed che hanno studiato la relazione tra effetti ossidativi e radiofrequenze a bassa intensità, in cellule viventi.

93 su 100 lavori evidenziano la induzione di effetti molecolari con la produzione di ROS , attivazione di perossidasi, danni ossidativi del DNA, enzimi, etc.

Conseguenze sono sia in condizioni favorevoli alla produzione di tumori che di elettrosensibilità


  

mercoledì 22 gennaio 2014

Le basse frequenze danneggiano il DNA cellulare

Questo studio recentissimo dà una conferma che la esposizione di cellule in vitro a radiazione a basse frequenze (100 Hz) ed un campo magnetico di 5,6 mT porta ad una significativa modifica con danneggiamento (quindi effetto GENOTOSSICO)  sulle cellule denominate VERO, che sono utilizzate per i test di laboratorio



Extremely low-frequency electromagnetic fields cause DNA strand breaks in normal cellsMihai CT, Rotinberg P, Brinza F, Vochita G. Extremely low-frequency electromagnetic fields cause DNA strand breaks in normal cells. J Environ Health Sci Eng. 2014 Jan 8;12(1):15. [Epub ahead of print]

Abstract

BACKGROUND:  Extremely low frequency electromagnetic fields aren't considered as a real carcinogenic agent despite the fact that some studies have showed impairment of the DNA integrity in different cells lines. The aim of this study was evaluation of the late effects of a 100 Hz and 5.6 mT electromagnetic field, applied continuously or discontinuously, on the DNA integrity of Vero cells assessed by alkaline Comet assay and by cell cycle analysis. Normal Vero cells were exposed to extremely low frequency electromagnetic fields (100 Hz, 5.6 mT) for 45 minutes. The Comet assay and cell cycle analysis were performed 48 hours after the treatment.

RESULTS:  Exposed samples presented an increase of the number of cells with high damaged DNA as compared with non-exposed cells. Quantitative evaluation of the comet assay showed a significantly (< 0.001) increase of the tail lengths, of the quantity of DNA in tail and of Olive tail moments, respectively. Cell cycle analysis showed an increase of the frequency of the cells in S phase, proving the occurrence of single strand breaks. The most probable mechanism of induction of the registered effects is the production of different types of reactive oxygen species.

CONCLUSIONS:  The analysis of the registered comet indices and of cell cycle showed that extremely low frequency electromagnetic field of 100 Hz and 5.6 mT had a genotoxic impact on Vero cells.

http://1.usa.gov/1eaOCVY