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mercoledì 29 luglio 2015

due grandi epidemiologici internazionali attaccano il NewYork Times

A seguito di una posizione del NYT contro la ordinanza di Berkely sulla obbligatorietà della etichettatura sulla pericolosità dei cellulari,  i due massimi ricercatori epidemiologi sulle EMF, Callberg e Hardell hanno scritto al giornale confutando, punto per punto, la lista di affermazioni false e tipo negazionista che il giornalista aveva utilizzato per deridere la ordinanza.

Riporto il testo della email, che è, secondo me, una fotografia della conoscenza su questa tematica.

 


Ms. Margaret Sullivan, Public Editor                                       July 24, 2015

Ms. Carol Pogash, Reporter

The New York Times

Regarding: Cellphone Ordinance Puts Berkeley at Forefront of Radiation Debate http://www.nytimes.com/2015/07/22/us/cellphone-ordinance-puts-berkeley-at-forefront-of-radiation-debate.html?_r=0
Published online July 21, 2015

Dear Ms. Sullivan and Ms. Pogash,

We have read this article in the New York Times with interest. However, there are several mistakes, and even wrong statements, on the health hazards from exposure to radiofrequency electromagnetic fields (RF-EMF) from cell phones in the article. In the following we want to correct some of the false statements.

The brain is the primary target organ for exposure to RF-EMF during the use of the handheld wireless phone. This has given concern of an increased risk for brain tumours. The carcinogenic effect of RF-EMF on humans was evaluated at a meeting during 24 – 31 May 2011 at the International Agency for Research on Cancer (IARC) at WHO in Lyon, France. One of us (LH) was part of the expert group. The Working Group categorised RF-EMF from mobile phones, and from other devices that emit similar non-ionising electromagnetic fields in the frequency range 30 kHz–300 GHz, as a Group 2B, i.e. a possible, human carcinogen (http://monographs.iarc.fr/ENG/Monographs/vol102/mono102.pdf

Since then more studies have been published that strengthen the association between use of  wireless phones (mobile and cordless phones) and increased risk for brain tumours. We have performed long-term research in this area and in the following we give a short up-dated summary of our findings based on research since the 1990’s. In our publications relevant information can be found also on other studies, as well as discussions of the current scientific evidence.
Glioma:
Glioma is a malignant brain tumour (“brain cancer”), and the most common type is glioblastoma multiforme with a poor prognosis. We have published a statistically significant increased risk for glioma among users of both mobile and cordless phones. The risk increased with latency (time from first use of the phone) and cumulative number of hours for use. Highest risk was found in the area of the brain with highest exposure to RF-EMF. All these results are of biological relevance; that is what would be expected for a causal association. The full paper can be read here:

Meningioma:
Menigioma is mostly a benign brain tumour and accounts for about 30 % of all intracranial tumours. The incidence is approximately 2-times higher in women than in men. No conclusive evidence of an association between use of mobile and cordless phones and meningioma was found in our study. However, taking the long latency periods that have been reported for the increased meningioma risk associated with exposure to ionizing radiation it is still too early to make a definitive risk assessment. Results for even longer latency periods of wireless phone use than in our study are desirable, see more details here:

Acoustic neuroma:
Acoustic neuroma or Vestibular Schwannoma is a rare benign tumour in the eighth cranial nerve that leads from the inner ear to the brain. It grows slowly and does not undergo malignant transformation, but may give compression of vital brain stem centres. Tinnitus and hearing problems are usual first symptoms of acoustic neuroma. We published a clear, statistically significant, association between use of mobile and cordless phones and acoustic neuroma. The risk increased with time since first use. For use of both mobile and cordless phones the risk was highest in the longest latency group. Tumour volume increased per 100 hours of cumulative use and year of latency for wireless phones indicating tumour progression from RF-EMF. The whole study can be read here:

Brain tumour incidence:
It is not correct to claim that the incidence of brain tumours has not increased in the Scandinavian countries. The age-standardized incidence of brain tumours increased dramatically in Denmark with +41.2 % among men and +46.1 % among women during 2003-2012 (http://www.ssi.dk/Aktuelt/Nyheder/2013/~/media/Indhold/DK - dansk/Sundhedsdata og it/NSF/Registre/Cancerregisteret/Cancerregisteret 2012.ashx).

Due to the well-known under-reporting of brain tumours to the Swedish Cancer Registry we studied brain tumour rates using the Swedish National Inpatient Register and the Causes of Death Register. In summary we found a statistically significant increasing rate of not specified brain tumours from 2007 in the Inpatient Register and from 2008 in the Causes of Death Register. Our study indicated that several of these tumours were never reported to the Swedish Cancer Register. Thus, the Swedish Cancer Register data cannot be used to dismiss an increased risk for brain tumours associated with use of wireless phones. On the contrary our study is consistent with an association considering a reasonable tumour induction period, see more here:

Mechanistic aspects:
It is correct that RF-EMFs do not cause direct DNA damage. On the other hand numerous studies have shown generation of reactive oxygen species (ROS) that can cause oxidative damage of DNA. This is a well-known mechanism in carcinogenesis for many agents. The broad biological potential of ROS and other free radicals makes radiofrequency radiation a potentially hazardous factor for human health, not only cancer risk but also other health effects. A recent update can be read here:

Causality:
To further evaluate strengths of evidence Bradford Hill wrote in the 1960’s a famous article on association or causation at the height of the tobacco and lung cancer controversy. Hill offered a list of nine aspects of an association to be considered when deciding if an association is causal. However, he did not request all nine viewpoints to be fulfilled for causality. We used the Hill criteria to evaluate the causality on brain tumor risk from RF-EMF emitted from wireless phones. We concluded that based on the Hill criteria, glioma and acoustic neuroma should be considered to be caused by RF-EMF emissions from wireless phones and regarded as carcinogenic to humans, classifying it as Group 1 according to the IARC classification. Current guidelines for exposure need to be urgently revised. See more here:

Conclusion:
Our results are in agreement with other studies such as the international Interphone -study and the French so-called CERENAT study. This is discussed in e.g. our article on glioma risk. In summary, there is consistent evidence of increased risk for glioma and acoustic neuroma associated with use of mobile phones and cordless phones. Furthermore, the risk is highest for persons with first use before the age of 20, which is of special concern. Our conclusion is that RF-EMF should be regarded as a human carcinogen. The IARC classification should be updated to at least Group 2A, a probable human carcinogen. It is necessary to give the public correct information on the cancer risk. The precautionary principle should be used to minimize exposure to RF-EMF. Media have an important role to inform in a balanced way. Unfortunately this article in the New York Times is biased towards the no risk assumption. It should be corrected based on facts and not wishful thinking.

Yours sincerely,

Lennart Hardell, MD, PhD               Michael Carlberg, MSc
Department of Oncology                  Department of Oncology
University Hospital                          University Hospital
SE-701 85 Örebro, Sweden             SE-701 85 Örebro, Sweden 
                               

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